Attachment and Trauma Network, Inc.
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Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia
There are no effective therapeutics for cognitive impairments associated with schizophrenia (CIAS), which includes deficits in executive functions (working memory and cognitive flexibility) and episodic memory. Compounds that have entered clinical trials are inadequate in terms of efficacy and/or tolerability, highlighting a clear translational bottleneck and a need for a cohesive preclinical drug development strategy. In this review we propose hippocampal–prefrontal-cortical (HPC–PFC) circuitry
Immune responses during embryo development could increase risk of schizophrenia
Past research has often highlighted the effects that immune activation in pregnant women can have on the development of human embryos, for instance increasing the risk of a child developing psychiatric disorders later in life. The neural mechanisms underpinning these effects, however, remain largely unclear.
Schizophrenia related to abnormal fatty metabolism in the brain
Researchers have discovered a deficiency in the brains of people with schizophrenia that could lead to the development of new drug therapies. A postmortem comparison revealed that schizophrenia was associated with lower than normal levels of S1P, a type of fatty molecule found in the white matter of the brain.
Researchers discover second type of schizophrenia
Penn Medicine researchers are the first to discover two distinct neuroanatomical subtypes of schizophrenia after analyzing the brain scans of over 300 patients. The first type showed lower widespread volumes of gray matter when compare to healthy controls, while the second type had volumes largely similar to normal brains. The findings, published Thursday in the journal Brain, suggest that, in the future, accounting for these differences could inform more personalized treatment options.
Study finds that lack of oxygen during pregnancy can cause schizophrenia
Lack of oxygen during the period anticipating child birth, a condition that may affect children of pregnant women subjected to a high blood pressure disorder called pre-eclampsia, has been found to be a cause of schizophrenia. In an article published in Scientific Reports, researchers at Santa Casa de São Paulo Medical School (FCM-SCSP) in Brazil described how this phenomenon, called hypoxia, affects astrocytes, one of the most abundant types of brain cell.
New clues into the genetic origins of schizophrenia
The first genetic analysis of schizophrenia in an ancestral African population, the South African Xhosa, appears in the Jan. 31 issue of the journal Science. An international group of scientists conducted the research, including investigators from Columbia University Mailman School of Public Health and New York State Psychiatric Institute, as well as the University of Cape Town and the University of Washington.
Hyperactive immune system gene causes schizophrenia-like changes in mice
Excessive activity of an immune system gene previously linked to schizophrenia reproduces neural and behavioral aspects of the disease in mice, according to a new study. The finding provides mechanistic support for the importance of the gene in the development of schizophrenia, and may offer a new avenue for therapy development.