Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis.Lepirudin may be used as an anticoagulant when heparins (unfractionated or low-molecular-weight) are contraindicated because of heparin-induced thrombocytopenia.
Heparin-Induced Thrombocytopenia: the reason why it is not recommended for use beyond 48 hrs. Other options besides UFH and LMWH (i. HIT assay to confirm and switch to argatroban for anticoagulant needs.