This image shows the Hsp90 chaperone cycle.

Protein That Kills Cells in Neurodegenerative Diseases Implicated in Cancer Cell Metabolism

Figure 1.  The distribution of hsp90A across a bacterial phylogeny.

Figure The distribution of across a bacterial phylogeny.

Schematic representation of the HSP90 inhibition-induced apoptosis in sensitive cells and in the context of acquired resistance.

Schematic representation of the inhibition-induced apoptosis in sensitive cells and in the context of acquired resistance.

The Hsp90/p23 system is directed and coupled to ATP hydrolysis.

The system is directed and coupled to ATP hydrolysis.

p23 accelerates the binding of ATP to Hsp90.

accelerates the binding of ATP to

p23 rearranges during ATP turnover of Hsp90.

rearranges during ATP turnover of

Label positions and their visualization.

Four-colour FRET reveals directionality in the multicomponent machinery

Possible mechanisms on how cochaperones act on their chaperone.

Four-colour FRET reveals directionality in the multicomponent machinery

MCL1 suppression and MCL1 addiction correlate with sensitivity to HSP90 inhibition.

suppression and addiction correlate with sensitivity to inhibition.

Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone Machineries

Oligomers Interacting with the Cochaperone: An Outlook for the Chaperone Machineries

Models for the mechanism of action of CDC37 in the chaperoning of kinase clients. Two models are proposed for the role of CDC37 in the chaperoning of kinase client proteins. Model A involves CDC37 directly binding to HSP90, thereby bringing kinase clients to the chaperone complex whereas Model B involves CDC37 altering kinases to promote their interaction with the chaperone complex as detailed in the numbered steps below.

Oncogene - Figure 10 for article: Restricting direct interaction of with does not compromise chaperoning of client proteins

CDC37 point mutations reduce binding to HSP90. Cartoons showing interactions between HSP90 and CDC37

point mutations reduce binding to Cartoons showing interactions between and

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